Molecular Rearrangements on Chromosome 1 lq23 Predominate in Infant Acute Lymphoblastic Leukemia and Are Associated With Specific Biologic Variables and Poor Outcome
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چکیده
Acute lymphoblastic leukemia (ALL) in infants generally shows distinctive biologic features and has a poor prognosis. Cytogenetic studies indicate that many infant leukemias have chromosome 1 1 q23 translocations. Because of these findings and the distinct clinical features of infant leukemia, we investigated 30 cases of infant ALL for molecular defects of l l q23. Fourteen cases had cytogenetic abnormalities of 1 1 q23, and all of them showed 1 1 q23 rearrangements at the molecular level. An additional seven cases also had 1 1 q23 molecular rearrangements, including one with normal cytogenetic analysis. Molecular abnormalities of 1 1 q23 were significantly correlated with adverse prognostic factors, including age under 6 months, hyper-
منابع مشابه
Molecular rearrangements on chromosome 11q23 predominate in infant acute lymphoblastic leukemia and are associated with specific biologic variables and poor outcome.
Acute lymphoblastic leukemia (ALL) in infants generally shows distinctive biologic features and has a poor prognosis. Cytogenetic studies indicate that many infant leukemias have chromosome 11q23 translocations. Because of these findings and the distinct clinical features of infant leukemia, we investigated 30 cases of infant ALL for molecular defects of 11q23. Fourteen cases had cytogenetic ab...
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